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Sarms cycle back to back

The method of claim 22, wherein the ghrelin variant increases expression level of UCP-2 in mitochondria, sarms cycle back to back. The method of claim 1, wherein the ghrelin variant prevents or reduces the metabolic consequence of mBI and any associated sequelae including chronic conditions. The method of claim 1, wherein the ghrelin variant prevents or reduces the rate or incidence of post-concussive syndrome. The method of claim 1, wherein the ghrelin variant is coupled to a protein that extends the serum half-life of the ghrelin variant. In some embodiments a peptide peptide is in a modified form of PEPTIDE ID NO: 86 comprising up to 2 amino acid modifications relative to PEPTIDE ID NO: 86, sarms cycle back to back.